Children's healthPreventive care

Enterovirus D68: top 5 must-know facts

Understand the symptoms and ways to prevent this infection.


LearnInfectionsHand, foot and mouth diseaseEnterovirus D68: top 5 must-know facts
What are the symptoms, and how is it diagnosed?
How is it spread?
Can it be treated or prevented?
Should I be concerned?

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Enterovirus D68 (EV-D68) is one of more than 100 similar viruses called non-polio enteroviruses. Although many of these viruses are very common, only small numbers of EV-D68 infections have been seen in the United States since 1987. In 2014, a nationwide outbreak of EV-D68 affecting 1,395 people led to many cases of severe respiratory illnesses in children, especially among children with asthma. Outbreaks occurred again in 2016 and 2018. The 2018 outbreak caused 96 percent of people diagnosed to be admitted to a hospital with 58 percent going to an intensive-care unit. The reason for these spikes in EV-D68 is unknown.

Recent research also indicates that EV-D68 is the probable cause of a spike in cases recorded in 2018 of acute flaccid myelitis (AFM), a polio-like condition that causes sudden weakness in the arms and legs.

Sources: Centers for Disease Control and Preventi... + 1
  1. Centers for Disease Control and Prevention. Enterovirus D68. Last reviewed: August 11, 2021.
  2. Fall A, Kenmoe S, Ebogo-Belobo et al. (2022) Global prevalence and case fatality rate of Enterovirus D68 infections, a systematic review and meta-analysis. PLoS Negl Trop Dis 16(2): e0010073.
Written by Michael Gollust.
Medically reviewed by Ann Wendling, MD, MPH.March, 2024
Updated onAugust, 2026
Written by Michael Gollust.
Medically reviewed by Ann Wendling, MD, MPH.March, 2024
Updated onAugust, 2026
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