General wellnessPreventive care

Lessons from the largest Ebola outbreak in history

Learn about the 2014 West African outbreak from a CDC expert—and understand the chances of an outbreak happening in the U.S.

Jan, 20263 min read
LearnInfectious diseasesEbola virus diseaseLessons from the largest Ebola outbreak in history
  • How does the 2014 Ebola outbreak compare with others?
  • What makes someone more or less likely to survive Ebola?
  • Are there any long-term effects of Ebola in survivors?
  • How does Ebola spread?
  • Is it likely that Ebola would spread through the United States?

Since Ebola disease was discovered in 1976, the largest outbreak occured in 2014 across several countries in West Africa. Over the course of the year, it killed an estimated 11,308 people in Guinea, Liberia, and Sierra Leone.

During a 25-year career with the Centers for Disease Control and Prevention (CDC), Cindy Whitney, MD, led emergency response task forces for several diseases, including SARS, pandemic influenza, and Ebola in West Africa. Here, Dr. Whitney shares insights on that outbreak—and whether you should be worried about the next one.

How does the 2014 Ebola outbreak compare with others?

Dr. Whitney: It was larger and went on longer. This was the first time Ebola has ever occurred in Guinea, Sierra Leone, and Liberia. And we had never seen Ebola spread so rapidly across borders or in urban areas before. Porous borders and a very mobile population made it easy for the disease to spread into cities and across countries and made it more difficult to control.

What makes someone more or less likely to survive Ebola?

Dr. Whitney: About half the cases that we know of result in death. What impacts survival is something we’re still investigating. Some basic interventions, when used early, can improve a patient’s chances of survival, so people who seek care early may have a better chance of surviving.

Are there any long-term effects of Ebola in survivors?

Dr. Whitney: Yes. We’re becoming aware of several potential long-term joint and vision problems. We’ve also found the virus in the semen of male survivors. That’s very concerning because it might be that they can spread Ebola after they’ve recovered. The Sierra Leone Ministry of Health & Sanitation, in collaboration with the Sierra Leone Ministry of Defense, WHO (World Health Organization), and CDC have been studying how long the virus might be found in semen.

How does Ebola spread?

Dr. Whitney: It’s thought that the first patient in an outbreak gets infected through contact with an animal that has the virus, such as a fruit bat or primate. Once it’s in people, it spreads in body fluids. Symptoms of the disease include vomiting, diarrhea, and unexplained bleeding, so caretakers can get sick when they clean infected fluids. People have also become sick when cleaning and preparing after someone dies, which is when the body is very contagious. And as I mentioned earlier, we’ve also found the virus in the semen of male survivors.

Is it likely that Ebola would spread through the United States?

Dr. Whitney: No, it’s not likely. In West Africa, CDC and partners use contact tracing to identify new Ebola cases quickly and to isolate patients as soon as they show symptoms. We also help officials in Guinea, Liberia, and Sierra Leone with exit screening at airports to prevent anyone who is sick from leaving the country. In the U.S., entry screening at five airports is another measure of protection. CDC works with U.S. Customs and Border Protection to identify any sick travelers or anyone who may have been exposed. Travelers are screened and, if needed, contacted by their local health department. We work with state and local health departments to make sure they’re aware of these travelers.

Although it’s unlikely, if a new case were diagnosed in the U.S., our healthcare system is now better prepared than it was prior to the first case. CDC is actively working with partners to train healthcare workers and expand the network of hospitals ready to treat patients with Ebola.

Sources: Centers for Disease Control and Prevention. Ebola. Outbreak History. May 6
  1. Centers for Disease Control and Prevention. Ebola. Outbreak History. May 6, 2024.
Written byPatrick Sullivan.
Medically reviewed byAnn Wendling, MD, MPH.May, 2024
Updated onMay, 2024
ask-md
AskMD
Curious about General wellness?
Written byPatrick Sullivan.
Medically reviewed byAnn Wendling, MD, MPH.May, 2024
Updated onMay, 2024
  • How does the 2014 Ebola outbreak compare with others?
  • What makes someone more or less likely to survive Ebola?
  • Are there any long-term effects of Ebola in survivors?
  • How does Ebola spread?
  • Is it likely that Ebola would spread through the United States?
ask-md
AskMD
Want to learn about General wellness?
Sources: Centers for Disease Control and Prevention. Ebola. Outbreak History. May 6
  1. Centers for Disease Control and Prevention. Ebola. Outbreak History. May 6, 2024.

Recommended for you

Infectious diseases
How Ebola spreads
Slideshow
Infectious diseases
Ebola timeline: tracking a deadly virus
Slideshow
Infectious diseases
What is bird flu—and should we be worried?
Article
Infectious diseases
What is mpox—and should you be worried?
Article
Infectious diseases
Antibiotic resistance: what to know and what to do about it
Article
AskMDHow can I be more consistent?
AskMd LogoAskMd Logo
Privacy policyConsumer health data privacyTerms of use
Cookie policyYour privacy choices

© 2026 Sharecare, Inc.