FibromyalgiaPain management

What causes fibromyalgia pain—and how can it be treated?

Learn about what may contribute to discomfort, plus potential avenues for helping to manage the condition.

Jan, 2026
LearnRheumatologyFibromyalgiaWhat causes fibromyalgia pain—and how can it be treated?
Slide 1
The Processing of Pain
The Toll That Stress Takes
The Medication Connection
A Stimulating Treatment Approach
Fibromyalgia and Sleep Apnea
Putting Research Into Action

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Slide 1

It can be hard living with fibromyalgia. In addition to persistent pain, the chronic condition often causes symptoms like fatigue, mental fogginess (brain fog), and digestive issues. It may also be difficult to diagnose and treat, which can add to the challenge.

While scientists don’t know exactly what causes fibromyalgia, they’re learning how pieces of the puzzle fit together. And having a better understanding of the disease can lead to faster diagnosis, more effective treatment, and ultimately, a better quality of life.

With that in mind, learn how brain chemicals, sleep patterns, stress—and more—could factor into fibromyalgia, plus newer avenues for treatment.

Written byMichael Gollust.
Medically reviewed byMegan Burke, MD.September, 2023
Sources: National Institute of Arthritis and Musculoskeletal and Skin Diseases. Fibromyalgia. Page last reviewed June 2021. + 16
  1. National Institute of Arthritis and Musculoskeletal and Skin Diseases. Fibromyalgia. Page last reviewed June 2021.
  2. Levey, Diana Kelly. Fibromyalgia Diagnosis. CreakyJoints.org. August 29, 2019.
  3. Mayo Clinic. Fibromyalgia. October 26, 2021.
  4. Centers for Disease Control and Prevention. Fibromyalgia. Page last reviewed January 6, 2020.
  5. Tsilioni I, Russell IJ, Stewart JM, et al. Neuropeptides CRH, SP, HK-1, and Inflammatory Cytokines IL-6 and TNF Are Increased in Serum of Patients with Fibromyalgia Syndrome, Implicating Mast Cells. J Pharmacol Exp Ther. 2016 Mar;356(3):664-72.
  6. Centers for Disease Control and Prevention. Coping with Stress. Page last reviewed April 25, 2023.
  7. Nardi AE, Karam EG, Carta MG. Fibromyalgia patients should always be screened for posttraumatic stress disorder. Expert Review of Neurotherapeutics. 2020 July;20(9):891-893.
  8. National Institute of Mental Health. Post-traumatic Stress Disorder. Page last reviewed May 2023.
  9. National Library of Medicine. Medication for the treatment of fibromyalgia. InformedHealth.org. March 8, 2018.
  10. Johns Hopkins Lupus Center. Fibromyalgia Medications. Accessed on June 26, 2023.
  11. Su YC, Guo YH, Hsieh PC, et al. Efficacy of Repetitive Transcranial Magnetic Stimulation in Fibromyalgia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Clin Med. 2021 Oct 12;10(20):4669.
  12. Chail A, Saini RK, Bhat PS, et al. Transcranial magnetic stimulation: A review of its evolution and current applications. Ind Psychiatry J. 2018 Jul-Dec;27(2):172-180.
  13. Sun P, Fang L, Zhang J, et al. Repetitive Transcranial Magnetic Stimulation for Patients with Fibromyalgia: A Systematic Review with Meta-Analysis. Pain Med. 2022 Mar 2;23(3):499-514.
  14. Meresh ES, Artin H, Joyce C, et al. Obstructive sleep apnea co-morbidity in patients with fibromyalgia: a single-center retrospective analysis and literature review. Open Access Rheumatol. 2019 Apr 29;11:103-109.
  15. Vantine F, Ettlin D, Meira-E-Cruz M. Resolution of fibromyalgia by controlling obstructive sleep apnea with a mandibular advancement device. Sleep Sci. 2021 Jul-Sep;14(3):291-295.
  16. Köseoğlu Hİ, İnanır A, Kanbay A, et al. Is There a Link Between Obstructive Sleep Apnea Syndrome and Fibromyalgia Syndrome? Turk Thorac J. 2017 Apr;18(2):40-46.
  17. Pinto, Vanessa L, Sharma, Sandeep. Continuous Positive Airway Pressure. StatPearls. Page last updated July 25, 2022.

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