Does the flu shot really save lives?

Everyone ages 6 months and older is advised to get a flu shot each year. But is this really necessary? The short answer: yes. Here’s what you need to know about the flu vaccine and why flu prevention is so essential—even for otherwise young, healthy people

The flu can be dangerous—even deadly

During the 2025-2026 flu season, at least 32,000,000 people got the flu. Of these people, at least 390,000 were hospitalized and 24,000 died as a result of their infections, according to the Centers for Disease Control and Prevention (CDC). But those are conservative estimates. The CDC reports there may have been up to 57 million infections, and up to 81,000 of them may have been fatal.

But the flu shot prevented those numbers from climbing even higher. The CDC points out the flu shot prevents millions of infections and tens of thousands of deaths each year.

But many people still think of the flu as a bad cold. This is not true.

Flu symptoms may seem like just a cold, but they’re usually more intense and linger longer. The stress the flu puts on the body can also lead to more serious complications, including pneumonia, inflammation of the heart, or stroke. People with other health issues, such as diabetes, heart disease, and lung disease are among those at greatest risk. Older people, pregnant people, and children are also at higher risk for flu-related complications.

Preventing the spread of the flu can not only keep you healthy but also protect the vulnerable people around you. Vaccinations are not just about one person. They help protect schools, communities, cities—even countries as a whole. When everyone who is eligible for a vaccine gets immunized, they provide a shield of protection for those who are not eligible. That shield of protection is called herd immunity. This happens when a virus or pathogen stops spreading because enough people are immune to it.

The best way to protect yourself and others who are more vulnerable: Get a flu shot.

What is the flu vaccine?

The precise formulations of the vaccine change every year, but the basic foundations of the vaccine remain constant. The shots are either made with flu viruses that have been inactivated, which means they’re not infectious, or they’re made without viruses at all (recombinant flu vaccines). This means that you can’t get the flu from any type of shot.

Depending on the year, both three-component (trivalent) or four-component (quadrivalent) vaccines may be available. Three-component vaccines defend against three types of flu virus: an influenza A (H1N1), another influenza A (H3N2), and an influenza B virus. The four-component vaccines protect against these same viruses, plus an additional B virus.

For the 2026-2027 flu season, the flu vaccine will include a change to protect against the so-called “super flu” or influenza A(H3N2) subclade K virus that spread widely during the 2025-2026 season. Subclade K is a mutated form of the influenza A strain H3N2, which is generally considered to be more severe, particularly among older people.

Certain vaccines are licensed for use in specific age groups, such as children and people older than 65.

In September 2026, an mRNA flu vaccine was approved by the U.S. Food and Drug Administration for adults ages 50 and older. It is the first flu shot to use mRNA technology. Clinical trials suggest it may be 26.6 percent more effective than traditional flu shots in this age group. The mRNA flu vaccine can also be produced more quickly than traditional vaccines (in just one to two months rather than five to six), which means they could be manufactured closer to the start of flu season. This could allow scientists to more closely match the flu strains in circulation.

Adults older than 65 years could also opt to receive the high-dose or adjuvanted flu vaccine, which is designed to trigger a stronger immune response.

Some groups of people are also not candidates for certain vaccines. Your healthcare provider (HCP) will recommend what is safe and appropriate for you, depending on your age, the health of your immune system, allergies, and other factors.

How is the flu vaccine selected?

Because the flu virus is constantly changing, researchers reevaluate the strains expected to be in circulation or spreading in communities each year. The exact components of the vaccine, therefore, may change from year to year. The World Health Organization (WHO) assembles a board of researchers from their own collaborating centers and other key laboratories—including the CDC and the Francis Crick Institute—to determine:

• Which viruses are making people sick
• How fast the viruses are spreading
• The effectiveness of the previous vaccine

Once this information has been presented and reviewed—usually in February of each year—the FDA makes the official vaccine decision for the United States. After that, manufacturing companies begin creating the vaccine, a process that usually takes about six months. Ideally, people in the U.S. should get their annual flu shot by the end of October.

In seasons when the vaccine is well-matched to most circulating influenza viruses, getting a flu shot may decrease the risk of needing medical care for the flu by 40 percent to 60 percent.

Who needs the shot?

The CDC recommends that everyone ages 6-months and older get the flu vaccine.

The more people who are vaccinated, the fewer chances the virus has to spread. But vaccination is particularly important for people who are at higher risk for severe flu and flu-related complications. This includes:

• Children younger than 5
• Adults older than 65
• People with chronic health issues or a weakened immune system
• Residents of nursing homes or other care facilities

Pregnant people should also get the flu shot during and after pregnancy. It can greatly reduce the risk of complications, such as preterm labor and preterm birth,and protect infants from illness for several months after birth. Babies younger than 6-months old are too young to be vaccinated but can still receive flu antibodies in the uterus, or before birth.

​There are some rare exceptions to the flu vaccine recommendations. People younger than 6-months old should not receive the flu vaccine. Some people with a history of Guillain-Barré Syndrome (GBS) should also not get a flu shot. (Guillain-Barré is a rare disorder in which your immune system attacks nerve cells causing muscle weakness and sometimes paralysis. Most people recover.) Those who have ever had GBS should talk to their healthcare provider (HCP) to determine if the flu vaccine is right for them.

The flu shot is also not recommended for those who’ve had severe allergic reactions to it in the past, or people who are allergic to certain vaccine components like gelatin or some antibiotics.

Egg allergies may be an exception. Many flu vaccines are made using egg-based technologies, but most people with egg allergies can still receive the flu vaccine without needing to be observed for an allergic reaction. In fact, the CDC says those with egg allergy may receive “any vaccine (egg-based or non-egg-based) that is otherwise appropriate for their age and health status.” People who are concerned about a severe egg allergy should discuss their options with their HCP.

There are alternatives for people with egg allergies. The recombinant flu vaccines is a laboratory-made vaccine that does not require use of a vaccine virus or chicken eggs in the manufacturing process. Eggs are also not used to make the mRNA flu vaccine, and it does not contain egg proteins.

Timing the flu shot

People should get their flu shot before the virus starts to spread each year. In the U.S. flu usually beings to circulate in October and peaks between December and February. But people can still get the flu as late as May.

The CDC recommends getting vaccinated by the end of October. Because children ages 6 months to 8 years who are getting vaccinated for the first time need two doses four weeks apart, it’s a good idea to begin their vaccination process even earlier.

And remember it takes two weeks to develop protective antibodies following immunization. This means that after you get a flu shot, it may take about two weeks for your body to gain protection against the flu. During that time, consider taking precautions against infections like the flu. This includes washing your hands well and often with soap and water, wearing a mask, and avoiding close contact with people who are sick, especially in poorly ventilated or crowded indoor spaces.