How bipolar disorder can impact physical health


LearnMental healthOvercoming bipolar disorderHow bipolar disorder can impact physical health
  • What health conditions are associated with bipolar disorder?
  • How can bipolar disorder affect physical health?

Bipolar disorders are a type of serious mental illness that cause a person to experience intense episodes of moods and emotions.

This includes manic episodes, where a person may feel very energized and euphoric—but also more likely to engage in risky and potentially dangerous behaviors. There are also depressive episodes, characterized by low moods and negative emotions, as well as mixed episodes, which feature both manic and depressive symptoms.

There are several types of bipolar disorder, and symptoms and the patterns of episodes can vary depending on the type.

Bipolar disorder can interfere with many different aspects of a person’s life, including work, relationships, and personal goals. Having bipolar disorder may also put a person at an increased risk of other health conditions and problems.

What health conditions are associated with bipolar disorder?

When compared to people who do not have bipolar disorder, people who have bipolar disorder are at an increased risk of several serious health conditions. Examples include:

  • High blood pressure (hypertension)
  • Cardiovascular disease
  • Type 2 diabetes
  • Obesity
  • Cancer
  • Substance use disorders
  • Sexually transmitted infections
  • Thyroid dysfunction
  • Migraines
  • Dental problems

How can bipolar disorder affect physical health?

The above is not a comprehensive list of health conditions that affect people with bipolar disorder. Likewise, having bipolar disorder is not a guarantee of having another health condition. Diseases like those above are often the result of several contributing factors.

Health behaviors

Because bipolar disorder affects behavior, it can affect many behaviors that are directly related to a person’s health.

  • This includes the foods a person eats, how physically active they are, and habits like smoking, alcohol consumption, and using recreational drugs.
  • People with bipolar disorder may also be more likely to skip preventive healthcare and screenings, delaying diagnosis and treatment for health conditions.
  • People with bipolar disorder may be more likely to engage in behaviors that increase the risk of accidents or sexually transmitted infections.

Genetics

Genetics are believed to play an important role in the development of bipolar disorder (though the genetics of bipolar disorder are unclear). While more research is needed, medical researchers believe that mental health disorders and other health conditions share common genetic risk factors. Cardiovascular disease is one example.

Poverty and childhood trauma

People who experience childhood trauma and/or poverty during childhood and adolescence are more likely to be diagnosed with bipolar disorder. Poverty is also considered a risk factor for many chronic diseases, including diabetes, cardiovascular disease, cancer, and substance use disorders. People experiencing poverty are also more likely to face barriers to care for any health condition.

Physical effects of mental illness

Mental illnesses like bipolar disorder can take a physical toll on the body—elevated heartrate, elevated blood pressure, elevated levels of cortisol (sometimes called the stress hormone). This may increase the risk of cardiovascular disease, metabolic disorders like type 2 diabetes, and obesity.

Medication side effects

Bipolar disorder is treated with medications, including mood stabilizers, neuroleptic drugs, and antidepressants. Different medications carry a different risk of side effects, but weight gain is a common side effect. Excess weight is a risk factor for many conditions, including type 2 diabetes and cardiovascular disease. Fatigue and drowsiness are other common side effects and may make it difficult to stay active or take care of oneself.

Staying healthy with bipolar disorder

Bipolar disorder is a serious mental illness that requires treatment—and getting and staying on treatment is the first step to staying healthy when living with bipolar disorder. Treatment for bipolar disorder is often overseen by a psychiatrist, a medical doctor that specializes in the treatment of mental health disorders.

In addition to working with a psychiatrist, work with a primary care provider. A primary care provider will oversee preventive care, recommended screenings, vaccinations, and referrals to any specialists you may need. A primary care provider can also advise you on ways to improve your health, including making changes to what you eat and how to exercise safely.

Your primary care provider and psychiatrist, as well as any other healthcare providers you are working with, should have shared access to your medical records. This includes any coexisting conditions you’ve been diagnosed with and all medications you are taking. A pharmacist is also an excellent source of information about drug interactions and side effects.

Sources: American Psychiatric Association. What A... + 21
  1. American Psychiatric Association. What Are Bipolar Disorders? April 2024.
  2. Substance Abuse and Mental Health Services Administration. Bipolar Disorder. April 24, 2023.
  3. MedlinePlus. Bipolar Disorder. October 17, 2023.
  4. World Health Organization. Bipolar Disorder. September 8, 2025.
  5. Sadaf Hossain, Pranita Mainali, et al. Medical and Psychiatric Comorbidities in Bipolar Disorder: Insights from National Inpatient Population-based Study. Cureus, 2019. Vol. 11, No. 9.
  6. Gerard Anmella, Giovanna Fico, et al. Risk of cancer in bipolar disorder and the potential role of lithium: International collaborative systematic review and meta-analyses. Neuroscience & Biobehavioral Reviews, 2021. Vol. 126.
  7. Shih-Fen Chen, Ling-Yi Wang, et al. Bipolar Disorder Is Associated With an Increased Risk of Sexually Transmitted Infections: A Nationwide Population-based Cohort Study. Sexually Transmitted Disease, 2018. Vol. 45, No. 11.
  8. Shengnan Zhao, Xu Zhang, et al. Comparison of thyroid function in different emotional states of drug-naïve patients with bipolar disorder. BMC Endocrine Disorders, 2021. Vol. 21.
  9. Jinfeng Duan, Rongmei Yang, et al. Comorbid Bipolar Disorder and Migraine: From Mechanisms to Treatment. Frontiers in Psychiatry. January 11, 2021.
  10. Syed Abdul-Wasay and Aviv Ouanounou. Dental and medical management of the patient with bipolar disorder. Special Care in Dentistry. March 15, 2023.
  11. National Institute of Drug Abuse. Tobacco, Nicotine, and E-Cigarettes Research Report: Do people with mental illness and substance use disorders use tobacco more often? January 2018.
  12. Efren J. Flores, Elyse R. Park, and Kelly E. Irwin. Improving Lung Cancer Screening Access for Individuals With Serious Mental Illness. Journal of the American College of Radiology, 2019. Vol. 16, No. 4, Pt. B.
  13. Shyh-Chyang Lee, Chang-Kuo Hu, et al. Risk of sexual transmitted infection following bipolar disorder: a nationwide population-based cohort study. Oncotarget, 2019. Vol. 9, No. 25.
  14. MedlinePlus Genetics. Bipolar disorder. February 9, 2021.
  15. Yann Quidé, Leonardo Tozzi, et al. The Impact of Childhood Trauma on Developing Bipolar Disorder: Current Understanding and Ensuring Continued Progress. Neuropsychiatric Disease and Treatment. December 14, 2020.
  16. Paul D. Hastings, Lisa A. Serbin, et al. Predicting psychosis-spectrum diagnoses in adulthood from social behaviors and neighborhood contexts in childhood. Development and Psychopathology, 2019.
  17. National Institute of Health. Stress links poverty to inflammation and heart disease. July 9, 2019.
  18. CDC Heart Disease. About Heart Disease and Mental Health. May 15, 2024.
  19. Mayo Clinic. Bipolar medications and weight gain. November 25, 2025.
  20. Mental Health America. I think my bipolar meds are making me feel worse. Accessed March 25, 2026.
  21. Mayo Clinic. Bipolar disorder. August 14, 2024.
  22. University Hospitals. Your Primary Care Provider Can Help Treat Your Mental Health, Too. March 21, 2021.
Written by Jameson Kowalczyk.
Medically reviewed by Joanne Perron, MD, MPH.March, 2026
Updated onAugust, 2026
Written by Jameson Kowalczyk.
Medically reviewed by Joanne Perron, MD, MPH.March, 2026
Updated onAugust, 2026
  • What health conditions are associated with bipolar disorder?
  • How can bipolar disorder affect physical health?

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