What’s Tay-Sachs disease?

Tay-Sachs is a genetic disease caused by a missing enzyme. Cynthia Tifft, MD, PhD, director of NIH’s Pediatric Undiagnosed Diseases Program, describes who develops the disease and how it’s diagnosed in infants.

Three examples of IRDs, and how different genetic eye diseases cause different types of vision loss.

Learn about these rare and very serious metabolic disorders.

This severe infection can lead to long-term complications—and even death—if not treated quickly and effectively.

Learn why hypertension in older adults is linked with stroke and dementia.

What is "frozen shoulder" exactly and why are some people more at risk than others?